Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, A new synthetic method of this compound is introduced below., SDS of cas: 6276-54-6
Large-Scale Synthesis of 3-Azidopropan-1-amineA solution of sodium azide (195 g, 3.0 mol) in deionized water (800 mL) was added into a three-neck round-bottom flask equipped with a condenser. Then 3-chloropropylamine hydrochloride (195 g, 1.5 mol) dissolved in 300 mL of deionized water was added. After continued stirring at 75-78 C. for 96 h, the white precipitate (NaCl) was removed as a byproduct from the reaction mixture by filtration. The yellow filtrate was basified with aqueous NaOH to pH?10-11 and further extracted with diethyl ether (5¡Á200 mL). The organic fraction was dried over anhydrous MgSO4 overnight, filtered, concentrated on a rotary evaporator, and distilled under reduced pressure to produce a colorless oil. The yield was: 108.4 g, 72%. 1H NMR (CDCl3, delta, ppm): 3.35 (t, 2H, CH2N3), 2.78 (t, 2H, NH2CH2), 1.71 (p, 2H, CH2CH2CH2), 1.27 (s, 2H, NH2).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Zhamu, Aruna; Jang, Bor Z.; US2013/5917; (2013); A1;,
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