Application of 886762-39-6, These common heterocyclic compound, 886762-39-6, name is 3,4-Dichloro-2-fluoroaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 Synthesis of Compound 11Will DCl (0.84mL, 12M,)Add to 3,4-dichloro-2-fluoroaniline (1.8g) in D2O (25mL)In the solution, the reaction was stirred at 180 C for 60 min under microwave. Cool to room temperature, adjust pH to basic with saturated sodium bicarbonate solution, dichloromethane (50 mL x 3).The organic layer was washed with saturated brine.Dry over anhydrous sodium sulfate,filter,The filtrate was concentrated under reduced pressure to give a brown solid1.8g.
The synthetic route of 886762-39-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Ren Xingye; (37 pag.)CN110054613; (2019); A;,
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