In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 63624-28-2 as follows. Safety of 2,4-Dimethoxybenzene-1-sulfonyl chloride
A solution of 0.28 g of the compound from Preparation 2.1 in 10 ml of THF is cooled to -30 C., 0.073 g of potassium tert-butoxide is added and the mixture is left stirring while allowing the temperature to rise to 0 C. The reaction mixture is cooled to -60 C., 0.147 g of the compound from Preparation 3.1 is added and the mixture is left stirring at 20 C. overnight. The reaction mixture is hydrolyzed by addition of water, extraction is carried out with AcOEt, the organic phase is dried over Na2SO4 and the solvent is evaporated under vacuum. The expected compound is obtained.
According to the analysis of related databases, 63624-28-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SANOFI-AVENTIS; US2011/59955; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics