Adding a certain compound to certain chemical reactions, such as: 108047-39-8, name is 2-(Aminomethyl)-4-chloroaniline, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 108047-39-8, Safety of 2-(Aminomethyl)-4-chloroaniline
A solution of the amine of preparation 10 (4.12 g, 26 MMOL) in tetrahydrofuran (50 mi) was added to a solution of the oxadiazole of preparation 6 (2.95 g, 11 MMOL) in tetrahydrofuran (50 ml) and heated to 50 C for 18 hours. The reaction mixture was evaporated under reduced pressure and the residue purified by chromatography on silica gel using ethyl acetate as eluant to give the title compound as an off-white solid (2.34 g). APCI MS M/Z 400 [MH] H NMR (400MHZ, CDCI3) : 5 1.80 (m, 2H), 2.20 (m, 2H), 3.20 (m, 3H), 3.80 (s, 2H), 4.00 (s, 2H), 4.75 (m, 2H), 6.50 (t, 1H), 6.60 (d, 1H), 7.00 (d, 1H), 7.05 (d, 1H), 8.35 (d, 2H).
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Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/74291; (2004); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics