Adding a certain compound to certain chemical reactions, such as: 261762-56-5, name is 1-Chloro-2-fluoro-3-methoxybenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 261762-56-5, Quality Control of 1-Chloro-2-fluoro-3-methoxybenzene
Example 40 Preparation of 2-(4-chloro-3-fluoro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dloxaborolane [0281] [0282] To a 100 mL flask charged with THF (25 mL) was added 1-chloro-2-fluoro-3-methoxybenzene (1 g, 6.23 mmol). The reaction flask was cooled to -78 C. in a dry ice acetone bath and n-butyllithium (0.399 g, 6.23 mmol) was added. After 40 min of stirring at -78 C. the reaction mixture was warmed to an internal temperature of -40 C. and the cooled to -78 C. in a dry ice acetone bath. 2-Isopropoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.159 g, 6.23 mmol) in THF (5 mL) was added in one portion. The dry ice/acetone bath was removed and the reaction mixture was allowed to warm to room temperature. The reaction mixture was nuetralized with 1N HCl solution and diluted with Et2O (50 mL) and water. The resulting organic layer was dried over Na2SO4, filtered and concentrated to give 1:1 mixture of 2-(4-chloro-3-fluoro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane and 2-(2-chloro-3-fluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane as light yellow oil that was used in the next step without further purification (300 mg): ESIMS m/z 271 ([M+H]+1).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Chloro-2-fluoro-3-methoxybenzene, and friends who are interested can also refer to it.
Reference:
Patent; Dow AgroSciences LLC; ECKELBARGER, Joseph D.; EPP, Jeffrey B.; FISCHER, Lindsey G.; GIAMPIETRO, Natalie C.; KISTER, Jeremy; PETKUS, Jeffrey; ROTH, Joshua; SATCHIVI, Norbert M.; SCHMITZER, Paul R.; SIDDALL, Thomas L.; YERKES, Carla N.; US2014/274703; (2014); A1;,
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