Related Products of 6276-54-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6276-54-6 as follows.
Preparation of Compound 1aDi-tert-butyl-dicarbonate (0.228 g, 1.04 mmol) and sodium hydroxide (0.096 g, 2.4 mmol) were added to a cooled solution of 3-chloropropan-1-amine (0.15 g, 1.04 mmol) in water (10 ml) and THF (10 ml). The resulting mixture was stirred overnight at 0 C. The aqueous layer was then extracted with ethyl acetate (10 ml¡Á4). The combined organic layer was washed with brine (25 ml), dried over sodium sulfate and concentrated. The residue was then purified by column chromatography on silica gel to afford 0.306 g of colorless oil. Yield: 94.0%. 1H NMR (300 MHz, CDCl3) delta1.39 (s, 9H), 81.91 (m, 2H), 83.23 (m, 2H), delta3.53 (t, J=6.4 Hz, 2H), 64.89 (s, 1H). 13C NMR (75 MHz, CDCl3) delta (ppm): 156.0, 79.2, 42.3, 37.9, 32.6, 28.3. MS (ESI): m/z calcd for C8H16ClNO2 193.09, found 193.52 [M+H]+
According to the analysis of related databases, 6276-54-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NANYANG TECHNOLOGICAL UNIVERSITY; US2012/288884; (2012); A1;,
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