Electric Literature of 24279-39-8, These common heterocyclic compound, 24279-39-8, name is 2,6-Dichloro-4-(trifluoromethyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
CuBr2 (4.02 g, 18.0 mmol) and tert-butyl nitrite (3.12 g, 30.3 mmol)were added together with MeCN (60 mL) to a three-necked flask underargon. In a separate flask, 2,6-dichloro-4-trifluoromethylaniline(3.5 g, 15.2 mmol) was dissolved in MeCN (20 mL) under argon. Theaniline solution was then added dropwise to the three-necked flaskcontaining the nitrite mixture. The reaction mixture was then heatedto 65 C and stirred overnight. The mixture was cooled to r.t. andpoured into a separatory funnel with H2O (50 mL) and Et2O (110 mL).The organic layer was separated and washed with aq 3 M HCl (2 ¡Á 30mL). The organic layer was dried (Na2SO4), concentrated by rotaryevaporation and high vacuum to completely remove the volatiles;yield: 3.79 g (85%); colorless oil.1H NMR (300 MHz, CDCl3): delta = 7.63 (s, 2 H).13C NMR (100 MHz, CDCl3): delta = 137.4, 131.1 (q, J = 34 Hz), 127.9, 125.2(q, J = 3.1 Hz), 122.4 (q, J = 271 Hz).
Statistics shows that 2,6-Dichloro-4-(trifluoromethyl)aniline is playing an increasingly important role. we look forward to future research findings about 24279-39-8.
Reference:
Article; Miller, Daniel K.; Bailey, Christopher A.; Sammelson, Robert E.; Synthesis; vol. 47; 18; (2015); p. 2791 – 2798;,
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