Electric Literature of 14862-52-3, These common heterocyclic compound, 14862-52-3, name is 3,5-Dibromochlorobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Potassium phosphate mono-hydrate (K3PO4.H2O, 8 g, 40 mmol, 2 equiv) and 1-chloro-3,5-dibromobenzene (2.4 g, 8.93 mmol) were added into the reaction solution of EXAMPLE 2, then refluxed at 110 C. overnight under argon atmosphere. Then cooled to ambient temperature. Distilled water (30 mL) was added via a funnel, and the resulting mixture was filtered on a Buechner funnel. The filtrate was transferred to a separatory funnel and extracted with CH2Cl2 (3¡Á50 mL). The combined organic phases were dried over Na2SO4, filtered on filter paper and concentrated to dryness by rotary evaporation (30 C., 25 mmHg). The resulting yellow solid was purified by column chromatography to afford 3.33 g white solid (90%). Compound G: 1H NMR (400 MHz, CDCl3). 8.97 (s, 2H), 8.67 (d, 2H), 8.08 (d, 2H), 7.84 (s, 2H), 7.76(s,1H), 7.73-7.71(m, 2H), 7.66-7.63 (m, 6H), 7.54-7.50 (m, 2H).
Statistics shows that 3,5-Dibromochlorobenzene is playing an increasingly important role. we look forward to future research findings about 14862-52-3.
Reference:
Patent; General Electric Company; US2010/331547; (2010); A1;,
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