Application of 3972-56-3, A common heterocyclic compound, 3972-56-3, name is 1-tert-Butyl-4-chlorobenzene, molecular formula is C10H13Cl, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(1) 800Kg of p-tert-butylchlorobenzene was added to the autoclave A, and the temperature of the reaction vessel A was controlled to 0 C, and the mixed acid was mixed with concentrated sulfuric acid and nitric acid at a temperature of 0 C,Nitric acid is 580L, and the temperature of the reactor A is raised to 20 C to 25 C. The reaction vessel A is stirred and the reaction is carried out overnight. After the reaction is completed, the reaction solution is poured into water to obtain an organic phase layer and an inorganic phase layer,And then the organic phase layer solution was dried and the ethyl acetate was recovered and distilled under reduced pressure to collect 180 C / 30 mmHg column fraction. The fraction was 1-chloro-4-tert-butyl 2-nitrobenzene;
The synthetic route of 3972-56-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Rudong Zhongyi Chemical Co., Ltd.; Ye Zhenjun; Dong Jiansheng; Yuan Shaozhi; Dai Yixu; Wang Zhengrong; Zhu Feng; Lu Jianhua; (7 pag.)CN105198710; (2017); B;,
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