7006-52-2, name is N-Methyl-3-chloroaniline, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C7H8ClN
TBAI in the reaction bottle (0.3mmol, 111 mg), compound1j (2mmol, 282 mg), compound2 (4mmol, 341 mg), NaOAc (4mmol, 164 mg), TBHP (0.60 ml), water (4.0 ml), tetrahydrofuran (4.0 ml). Then the system in the air 80 ¡ãC heating under the conditions of about 12 hours, quenched with saturated sodium sulfite solution, extraction with ethyl acetate (40 ml ¡Á 3), silica gel adsorption, through the simple column chromatography can get product3j,the yield is 75percent. The prepared test data mainly of the product are as follows, can be known through the analysis, the actual synthetic product is consistent with the theoretical analysis.
The synthetic route of 7006-52-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Suzhou University; Wan, Xiaobing; Wang, Hongxiang; Zhang, Jie; Shao, Ying; (22 pag.)CN105237435; (2016); A;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics