Related Products of 29671-92-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29671-92-9 name is Carbamimidic chloride hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
INTERMEDIATE 7 2-Aminothieno [3 ,4-d]pyrimidin-4-ol A mixture of methyl 4-aminothiophene-3-carboxylate (1.0 g, 6.4 mmol), chioro5 formamidine hydrochloride (1.83 g 15.9 mmol) and dimethyl sulfone (2.99 g, 31.8 mmol)was finely ground with a pestle and mortar, and the mixture was heated at 130C for 40 minutes. Water was poured into the reaction mixture, and concentrated ammonia solution was added to basify the reaction solution (ice bath). The precipitate was collected, washed with water and dried in vacuo, to provide the title compound (0.99 g, 92%) as ayellow solid. ?3C NMR (75 MHz, DMSO-d6) oe 159.7, 151.4, 148.8, 127.4, 123.7, 108.4. MS m/z (%) 168 [M+H].
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Carbamimidic chloride hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; FORD Daniel James; HUANG Qiuya; NEUSS Judi Charlotte; REUBERSON James Thomas; VANDERHOYDONCK Bart; WO2015/193168; (2015); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics