7781-10-4, name is 4-Chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, belongs to chlorides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 7781-10-4
Using General Procedure 3 to prepare Rlb and iodobenzene as reagents, 4-methoxy-7-phenyl-pyrrolo[2,3-d]pyrimidine (without hydrolysis) was obtained.The crude product (450 mg, 2 mmol) was dissolved in THF (18 ml), stirred at -78 C, then LDA solution (1.8 M, 1.7 ml, 3 mmol) was added. After stirring at -78 C for one hour, a solution of iodomethane (190 mul, 3 mmol) in THF (5 ml) was added and stirring was continued for 90 minutes. The reaction mixture was then diluted with brine (10 ml) and evaporated to Celite and purified by flash chromatography (hexane-EEO = 7-1).
The synthetic route of 7781-10-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD; KOTSCHY, ANDRAS; WEBER, CSABA; VASAS, ATTILA; MOLNAR, BALAZS; KISS, ARPAD; MACIAS, ALBA; MURRAY, JAMES BROOKE; LEWKOWICZ, ELODIE; GENESTE, OLIVIER; CHANRION, MAIA; DEMARLES, DIDIER; IVANSCHITZ, LISA; (502 pag.)TW2018/2094; (2018); A;,
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