Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 329944-72-1, name is 3-Bromo-5-chlorotoluene, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 3-Bromo-5-chlorotoluene
S-Chloro-S-metbyl-benzonitrile To a stirred soiution of 1-Bromo-3-chloro-5-methyl- benzene (7 32g, 35 62mmol) in DMF (70ml), were added zinc cyanide (2.51g, 21 37mmol), DPPF (395mg, 0 712mmol), and Pd2dba3 (326mg, 0.356mmol) in this order. The flask was flushed with nitrogen and stirred in an oil bath (110-1200C) for 5hr After cooling to room temperature, the mixture was evaporated in vacuo. The residue was purified by silica gel column chromatography (eluent, etherhexane (from 1 ’19 to 1 9)) to afford 2.8g (51%) of a paie yellow solid m.p. 74-76 0C, 1H-NMR(200MHz, CDCi3) delta 2 39(3H s), 7 35(1 H, s), 7.40(1 HT s), 7.44(1 H, s), m/z (El) 151(M+).
According to the analysis of related databases, 329944-72-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; KIM, Choung, U.; MITCHELL, Michael, L.; SON, Jong, Chan; WO2010/9047; (2010); A1;,
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