Extracurricular laboratory: Synthetic route of 13078-79-0

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(3-Chlorophenyl)ethanamine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 13078-79-0, name is 2-(3-Chlorophenyl)ethanamine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13078-79-0, Recommanded Product: 13078-79-0

Step v) 3-(3-ChlorophenethyIamino)-N-cycIoheptyl-N-(2-(2-(8-hydroxy-2-oxo-l,2- dihydroquinolin-5-yl)ethylamino)ethyl)propanamide bis(trifluoroacetate)Benzyl 2-(N-cycloheptylacrylamido)ethyl(2-(8-hydroxy-2-oxo- 1 ,2-dihydroquinolin-5- yl)ethyl)carbamate (100 mg) [Step iv] and 2-(3-chlorophenyl)ethylamine (88 mg) were combined in ethanol (1.1 mL) and and heated within a CEM Discover microwave at 100 0C until the reaction was completed, as judged by LCMS (30 minutes). The mixture was then concentrated in vacuo prior to addition of acetic acid (3 mL) followed by 33% HBr in acetic acid (2 mL). The resulting solution was stirred for 2 h then concentrated in vacuo and the residue purified by reverse phase preparative HPLC (eluting with acetonitrile 0.1%5 aqueous trifluoroacetic acid). Product containing fractions were combined and concentrated in vacuo to afford the title compound as a solid (50 mg). MS (APCI+) 553 [M+H]+ 1H NMR (399.826 MHz, DMSO) delta 10.47 (s, IH), 10.34 (s, IH), 8.62 – 8.46 (m, 4H), 8.08 – 8.01 (m, IH), 7.41 – 7.31 (m, 3H), 7.27 – 7.22 (m, IH), 6.94 – 6.87 (m, 2H), 6.58 io (d, J = 10.0 Hz, IH), 3.72 – 3.63 (m, IH), 3.49 – 3.43 (m, 2H), 3.30 – 3.01 (m, 10H), 2.99 – 2.92 (m, 2H), 2.85 – 2.79 (m, 2H), 1.80 – 1.37 (m, 12H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(3-Chlorophenyl)ethanamine, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/75025; (2008); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics