Adding a certain compound to certain chemical reactions, such as: 14862-52-3, name is 3,5-Dibromochlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14862-52-3, COA of Formula: C6H3Br2Cl
Synthesis of Intermediate I-6 (0251) 1,3-dibromo-5-chlorobenzene (100 g, 370 mmol) was dissolved in THF (2 L) in a nitrogen environment, phenylboronic acid (47.3 g, 388 mmol) and tetrakis(triphenylphosphine)palladium (Pd(PPh3)4) (1.5 g, 1.36 mmol) were added thereto, and the mixture was stirred. Potassium carbonate (K2CO3) (127 g, 925 mmol) saturated in water was added thereto, and the resulting mixture was heated and refluxed at 80 C. for 12 hours. When the reaction was complete, water was added to the reaction solution, the mixture was extracted with dichloromethane (DCM), and an extract therefrom was filtered and concentrated under a reduced pressure after removing moisture with anhydrous MgSO4. The obtained residue was separated and purified through flash column chromatography to obtain an intermediate I-6 (49 g, 50%). (0252) HRMS (70 eV, EI+): m/z calcd for C12H8BrCl: 265.9498, found: 266 Elemental Analysis: C, 54%; H, 3%
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dibromochlorobenzene, and friends who are interested can also refer to it.
Reference:
Patent; SAMSUNG SDI CO., LTD.; OH, Jaejin; KANG, Giwook; KANG, Eui Su; KIM, Youngkwon; KIM, Younhwan; KIM, Hun; PARK, Jaehan; YU, Eun Sun; JUNG, Ho Kuk; CHO, Pyeongseok; (174 pag.)US2017/98778; (2017); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics