Synthetic Route of 4152-90-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4152-90-3 as follows.
To compound 2 (3 g, 9.2 mmol) at room temperatureEthanol (50mL)Et3N (2.6 mL, 18.4 mmol) was added to the solution.And 3-chlorobenzylamine (2.1 mL, 18.4 mmol),The resulting mixture was stirred at 40 ¡ã C for 5 h;Concentrated and the residue is purified by silica gel column(by volume ratio, DCM: MeOH: NH3¡¤H2O=200:10:0.1),Obtaining colorless oily compound 3(3.13g, 82percent),
According to the analysis of related databases, 4152-90-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Bio-technology Institute; The Chinese People’s Liberation Army Military Academy Of Sciences Military Medical Institute; Liu Mingliang; Lv Kai; Zhong Wu; Cao Ruiyuan; Wang Apeng; Yan Yunzheng; Tao Zeyu; He Qinghao; Wang Hongjian; Li Wei; Geng Yunhe; (29 pag.)CN108892693; (2018); A;,
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