Adding a certain compound to certain chemical reactions, such as: 3972-56-3, name is 1-tert-Butyl-4-chlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3972-56-3, category: chlorides-buliding-blocks
General procedure: An oven-dried Schlenk tube was evacuated and backfilled with nitrogen. The Schlenk tube was charged with NaH (60.0 mg, 60percent,1.2 mmol) and o-xylene (1 mL), and then phenol (1.2 mmol) wasadded. After stirring for 15 min, aryl halide (1.0 mmol) and the solution of Pd(dba)2 (11.5 mg, 0.02 mmol) and L1 (13.7 mg, 0.03 mmol) in o-xylene (1.5 mL) were added sequentially. The septum was replaced with an inside reflux condenser, and then the reaction mixture was stirred for 18 h at 110 C. Then, reaction mixture was cooled to room temperature and quenched with saturated NH4Cl(5 mL). After separating the organic phase, the aqueous phase was extracted with diethyl ether (3 mL3), and the combined organic phase was dried over anhydrous Na2SO4. The solvent was concentrated under reduced pressure, and then the crude material was purified by column chromatography on silica gel.
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Reference:
Article; Zhang, Yi; Ni, Gang; Li, Chengjun; Xu, Sheng; Zhang, Zhaoguo; Xie, Xiaomin; Tetrahedron; vol. 71; 30; (2015); p. 4927 – 4932;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics