Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 57310-39-1, name is 3-Bromo-4-chlorotoluene, A new synthetic method of this compound is introduced below., Formula: C7H6BrCl
A solution of 2-bromo- l -chloro-4-methylbenzene (24 g, 0. 1 17 mo l, l eq) in cone. H2S04 (200 mL) was cooled to 0-5C. Nitric acid (5 mL, 1.48g/ml, 0.1 17mol) in cone. H2S04 ( 13 ml) was added dropwise to the mixture slowly. After the addition was completed, the reaction was stirred at 0 C for 3h. The reaction mixture was poured into 200g ice-water and extracted with DCM (2×100 mL). The combined organic layers were washed with water , dried over Na2S04, and concentrated to afford crude 166, which was recrystallized from ethanol (200ml) to afford 166 as a pale yellow solid (24 g, 83%). ? NM (400 MHz, CDCb) ppm: 8.08 (s, 1H), 7.63 (s, 1 H), 2.56 (s, 3H).
The synthetic route of 57310-39-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AFRAXIS, INC.; CAMPBELL, David; DURON, Sergio, G.; WO2013/43232; (2013); A2;,
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