Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 10147-36-1, Name is Propane-1-sulfonyl chloride, SMILES is CCCS(=O)(Cl)=O, in an article , author is Hansen, Esben Sovso Szocska, once mentioned of 10147-36-1, Computed Properties of C3H7ClO2S.
Veno-occlusive unloading of the heart reduces infarct size in experimental ischemia-reperfusion
Mechanical unloading of the left ventricle reduces infarct size after acute myocardial infarction by reducing cardiac work. Left ventricular veno-occlusive unloading reduces cardiac work and may reduce ischemia and reperfusion injury. In a porcine model of myocardial ischemia-reperfusion injury we randomized 18 pigs to either control or veno-occlusive unloading using a balloon engaged from the femoral vein into the inferior caval vein and inflated at onset of ischemia. Evans blue and 2,3,5-triphenyltetrazolium chloride were used to determine the myocardial area at risk and infarct size, respectively. Pressure-volume loops were recorded to calculate cardiac work, left ventricular (LV) volumes and ejection fraction. Veno-occlusive unloading reduced infarct size compared with controls (Unloading 13.9 +/- 8.2% versus Control 22.4 +/- 6.6%; p = 0.04). Unloading increased myocardial salvage (54.8 +/- 23.4% vs 28.5 +/- 14.0%; p = 0.02), while the area at risk was similar (28.4 +/- 6.7% vs 27.4 +/- 5.8%; p = 0.74). LV ejection fraction was preserved in the unloaded group, while the control group showed a reduced LV ejection fraction. Veno-occlusive unloading reduced myocardial infarct size and preserved LV ejection fraction in an experimental acute ischemia-reperfusion model. This proof-of-concept study demonstrated the potential of veno-occlusive unloading as an adjunctive cardioprotective therapy in patients undergoing revascularization for acute myocardial infarction.
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