Let¡¯s face it, organic chemistry can seem difficult to learn, Recommanded Product: 2687-12-9, Especially from a beginner¡¯s point of view. Like 2687-12-9, Name is Cinnamyl chloride, molecular formula is chlorides-buliding-blocks, belongs to chlorides-buliding-blocks compound. In a document, author is Wang, Ying, introducing its new discovery.
Pathological thrombosis within a vessel hampers blood flow and is the mainspring of numerous fatal cardiovascular complications. In order to specifically image and dissolve a thrombus, we rationally designed a functionalized polymeric hybrid micelle (PHM) system self-assembled from amphiphilic polycaprolactone-polyethylenimine (PCL-PEI) and polycaprolactone-polyethylene glycol (PCL-PEG). Based on a biological component of thrombi, activated coagulation factor XIII (FXIIIa), which is responsible for fibrin crosslinking, we further developed FXIIIa-targeted near infrared imaging and thrombolytic nanoparticles, termed IR780/FPHM/LK NPs, through chemical conjugation of peptides to the system. In a ferric chloride (FeCl3)-induced mouse carotid thrombosis model, IR780/FPHM/LK NPs specifically targeted the thrombus and significantly enhanced the photoacoustic signal for an accurate diagnosis. When loaded with the fibrinolytic drug lumbrokinase (LK), FPHM remarkably dissociated the thrombus accompanied by an increase in the D-dimer level, a fibrin degradation product, and alleviation of fatal nonspecific hemorrhagic risk. Given its thrombus-specific imaging along with potent therapeutic activities, IR780/FPHM/LK NPs hold promise for developing nanotheranostic agents in preclinical thrombotic vascular disease models. Statement of significance In this study, we developed a functionalized polymeric hybrid micelle system self assembled from amphiphilic copolymers, polycaprolactone-polyethylenimine (PCL-PEI) and polycaprolactone-polyethyleneglycol (PCL-PEG). The conjugation of FXIII peptide could facilitate the specific delivery of the system to the FXIIIa-rich thrombosis site. In a FeCl3-induced mouse arterial thrombosis model, the system could specifically image thrombosed vessels and exert significant thrombolytic effect without affecting normal hemostatic function, through the delivery of near-infrared imaging probe and fibrinolytic drug simultaneously. Therefore, this system has great potential for high-performance delivery of proteinase and near-infrared probe to thrombosis site, achieving diagnosis and treatment of arterial thrombosis disease.(C) 2020 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
If you are hungry for even more, make sure to check my other article about 2687-12-9, Recommanded Product: 2687-12-9.
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics