Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 98946-18-0, Name is tert-Butyl trichloroacetimidate, molecular formula is C6H10Cl3NO. In an article, author is Fiore, Michele,once mentioned of 98946-18-0, Product Details of 98946-18-0.
Prodiginines and tambjamines are anion-selective ionophores capable of facilitating the transport of anions across the plasma membrane in mammalian cells. One of the potential applications of these anionophores is the possibility of employing them as a substitutive therapy for pathologies involving anion channels, as in cystic fibrosis. We have studied the interaction of a large anion as gluconate with three prodiginineand two tambjamine-like compounds. Apparent dissociation constants for the chloride, iodide and gluconate complexes were estimated from iodide influx experiments in mammalian cells exposed to different extracellular anion combinations. Our experiments indicate that gluconate is not transported by the prodiginines, leaving the anionophores free to transport chloride and iodide. Conversely, gluconate would be transported to some extent by the tambjamines, competing with halides for the anionophores, and consequently reducing their flux. This might be related to the different structural features of both families of compounds. These data have important implications for the selection of impermeable anions in the analysis of the anionophore mechanism.
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Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics