Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 126-83-0, Name is Sodium 3-chloro-2-hydroxypropane-1-sulfonate, molecular formula is C3H6ClNaO4S, belongs to chlorides-buliding-blocks compound, is a common compound. In a patnet, author is Chen, Ying, once mentioned the new application about 126-83-0, Recommanded Product: 126-83-0.
alpha-(Hetero)aryl nitriles are important structural motifs for pharmaceutical design. The known methods for direct synthesis of these compounds via coupling with (hetero)aryl halides suffer from narrow reaction scope. Herein, we report that the combination of copper salts and oxalic diamides enables the coupling of a variety of (hetero)aryl halides (Cl, Br) and ethyl cyanoacetate under mild conditions, affording alpha-(hetero)arylacetonitriles via one-pot decarboxylation. Additionally, the CuBr/oxalic diamide catalyzed coupling of (hetero)aryl bromides with alpha-alkyl-substituted ethyl cyanoacetates proceeds smoothly at 60 degrees C, leading to the formation of alpha-alkyl (hetero)arylacetonitriles after decarboxylation. The method features a general substrate scope and is compatible with various functionalities and heteroaryls.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 126-83-0. The above is the message from the blog manager. Recommanded Product: 126-83-0.
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics