Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition, 74-11-3, Name is 4-Chlorobenzoic acid, SMILES is O=C(O)C1=CC=C(Cl)C=C1, in an article , author is Al-Hussain, Sami A., once mentioned of 74-11-3, Application In Synthesis of 4-Chlorobenzoic acid.
Hydrazonoyl halides have been known for their ability to react with different reagents to afford wide range of bioactive heterocyclic systems as thiazoles and imidazopyrazoles. This research work focused on the synthesis of two new fluorinated hydrazonoyl chlorides and used them in synthesis of novel series of thiazole derivatives and two imidazopyrazole systems. The mechanistic pathways and the structures of all synthesized derivatives were discussed and assured based on the available spectral data. The results of antimicrobial activity of the tested thiazoles and imidazopyrazoles showed that some derivatives have moderate to no activity against tested fungi and bacteria strains. Only one derivative namely 2-(2-(3-fluoro-4-methylphenyl)hydrazono)-7-(2-oxoindolin-3-ylidene)-2,7-dihydro-3H-imidazo[1,2-b]pyrazole-3,6(5H)-dione is the most active against Candida albicans (CA) with IZD = 20 mm, which was equipotent to ketoconazole. Furthermore, docking simulation was carried out to predict the binding pattern of the new compounds in the ATP binding site of the DNA gyrase B enzyme. The results of the docking simulation revealed that compounds 9a-e, 12, and 13a,b fit well in the ATP binding site of DNA gyrase B with docking score values ranging from -5.883 to -6.833 kcal/mol.
But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 74-11-3, you can contact me at any time and look forward to more communication. Application In Synthesis of 4-Chlorobenzoic acid.
Reference:
Chloride – Wikipedia,
,Chlorides – an overview | ScienceDirect Topics