Adding a certain compound to certain chemical reactions, such as: 3972-56-3, name is 1-tert-Butyl-4-chlorobenzene, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3972-56-3, category: chlorides-buliding-blocks
General procedure: To an ice-cold mixture of DPMPA (816 mg, 3.76 mmol) and THF (3.0 mL) was added 1.50 mL of a 2.5 M solution of n-BuLi (3.8 mmol) in hexane. This mixture was stirred for 5 min, and 9.7 mL of a 0.097 M solution of SmI2 (0.94 mmol) in THF was added, and stirred for 5 min. After cooling the reductant to -66 C, a solution of the organochlorine substrate (0.285 mmol) and t-BuOH (54 muL, 0.57 mmol) in THF (1.4 mL) was added. The mixture was allowed to warm to 21 C over 2 h and, where appropriate, tetradecane (10.0 muL, 0.0384 mmol) was added. Water (8 mL) was added, and the mixture was extracted with a 2:1 mixture of hexanes and Et2O (5¡Á5 mL). The concentrated mixture was purified by silica gel column chromatography.
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Reference:
Article; McDonald, Chriss E.; Ramsey, Jeremy R.; Sampsell, David G.; Anderson, Laura A.; Krebs, Jordan E.; Smith, Samantha N.; Tetrahedron; vol. 69; 14; (2013); p. 2947 – 2953;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics