Synthetic Route of 6276-54-6, The chemical industry reduces the impact on the environment during synthesis 6276-54-6, name is 3-Chloropropan-1-amine hydrochloride, I believe this compound will play a more active role in future production and life.
3-Chloropropylamine hydrochloride (1.85g, 14.2mmol) is suspended in toluene (20mL). 1.0mL of 37w% formaldehyde solution (13.4mmol) is added, then once the solids have dissolved KOH (930mg, 14.1mmol based on 85% purity) is also added. The mixture is stirred for 5h. The clear toluene phase is taken from the white paste and filtered through MgSO4. The solids are extracted with a further 1mL of toluene. The combined solutions are pumped down and the residue is dried under high vacuum for 1hr to leave a colourless oil (1.298g, 4.1mmol, 93%) which turns cloudy within a few hours. 1H NMR (m-PhF set to 7.072): delta=3.39 (6H, t, J=6.4, -CH2Cl), 3.12 (6H, s, NCH2N), 2.38 (6H, t, J=6.6, TACCH2-), 1.64 (6H, quintet, J=6.5, -CH2CH2Cl). 13C NMR – 1H-coupled, (m-PhF set to 130.476): delta=74.6 (t of quintets, J=143/4.6, NCH2N), 49.6 (t, J=133, TAC-CH2-), 43.3 (t of quintets, J=151/4.2, -CH2Cl), 31.1 (t of t, J=128/2.8, -CH2CH2Cl).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Chloropropan-1-amine hydrochloride, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Koehn, Randolf D.; Coxon, Alexander G.N.; Hawkins, Christopher R.; Smith, David; Mihan, Shahram; Schuhen, Katrin; Schiendorfer, Michael; Kociok-Koehn, Gabriele; Polyhedron; vol. 84; (2014); p. 3 – 13;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics