Related Products of 626-43-7,Some common heterocyclic compound, 626-43-7, name is 3,5-Dichloroaniline, molecular formula is C6H5Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Anhydrous TFA (3e5 drops) was added into appropriatelysubstituted aniline (10 mmol) and then heated to 100 C. To thismixture was added 3mL of ethyl acrylate (EA) within 10min, andthe mixture was stirred at 100 C for 24 h. After this period the EAwas removed under vacuum. The resulted residue was purified bysilica gel chromatography to yield compound 6.
The synthetic route of 626-43-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Liu, Qi; Shi, Wei-Kang; Ren, Shen-Zhen; Ni, Wei-Wei; Li, Wei-Yi; Chen, Hui-Min; Liu, Pei; Yuan, Jing; He, Xiao-Su; Liu, Jia-Jia; Cao, Peng; Yang, Pu-Zhen; Xiao, Zhu-Ping; Zhu, Hai-Liang; European Journal of Medicinal Chemistry; vol. 156; (2018); p. 126 – 136;,
Chloride – Wikipedia,
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