Adding a certain compound to certain chemical reactions, such as: 13526-66-4, name is 3-Bromo-6-chloroimidazo[1,2-b]pyridazine, belongs to chlorides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13526-66-4, Safety of 3-Bromo-6-chloroimidazo[1,2-b]pyridazine
General procedure: Example 15-5 General procedure for the synthesis of 3-bromo-6-R1-imidazo[1,2-b]pyridazine 4*. (R1= aminyl) by amine (R1H) displacement A mixture of 3-bromo-6-chloroimadazo[1,2-b]pyridazine 2*a (15 g, 64.52 mmol, 1 eq.), the appropriate amine (R1H, 96.78 mmol, 1.5 eq.) and DIPEA (16.90 ml, 96.78 mmol, 1.5eq.) in ethanol (15 ml) was placed in the CEM Microwave and stirred and heated at 160 C for 10 minutes and 180 C for 2 hours. The solvent was removed under reduced pressure. The residue was dissolved in ethyl acetate, washed with water (twice) and brine and then filtered through a pad of silica and washed with ethyl acetate. The organic solvent was evaporated under reduced pressure and the crude residue was slurried in hexane/10% ether. The crystalline product was filtered and washed with hexane/ 10% ether and dried to give the intermediate 3-bromo-6-R1-imidazo[1,2-b]pyridazine 4*.
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Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.; Ullrich, Axel; Falcenberg, Mathias; EP2818471; (2014); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics