Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16793-91-2, name is 2-Chlorophenethyl Bromide, This compound has unique chemical properties. The synthetic route is as follows., name: 2-Chlorophenethyl Bromide
Example 14: Preparation of 8-r2-(2-chlorophenyl)ethvn-3-methyl-4-((4-r3- (trifluoromethyl)phenynpiperazin-1-yl>carbonyl)-1-oxa-8-azaspiror4.51dec-3-en-2-oneA mixture of 3-methyl-4-({4-[3-(trifluoromethyl)phenyl]piperazin-1-yl}carbonyl)-1 -oxa-8- azaspiro[4.5]dec-3-en-2-one dihydrochloride (Example 1 , 200 mg, 0.40 mmol), anhydrous potassium carbonate (180 mg, 1.30 mmol) and 1-(2-bromo-ethyl)-2-chloro-benzene (0.07 mL, 0.22 mmol) in anhydrous N.N-dimethylformamide (3 mL) was heated at 90C for 1.5 hours under microwave irradiation. The reaction mixture was concentrated under vacuum. The residue was taken up in dichloromethane (20 mL), washed with water (20 mL) and brine (20 mL), dried (MgS0 ) and concentrated under vacuum. After purification by flash chromatography (silica), the title compound was obtained as a white solid. 1H NMR (DMSO-d6, 400 MHz): delta 7.46-7.34 (m, 3H), 7.26-7.23 (m, 4H), 7.11 (d, J = 7.5 Hz, 1 H), 3.80-3.79 (m, 1 H), 3.68-3.69 (m, 1 H), 3.56 (s, 2H), 3.27 (s, 1 H), 3.16-3.15 (m, 2H), 2.93-2.92 (m, 1 H), 2.87-2.83 (m, 4H), 2.53 (s, 2H), 2.25-2.24 (m, 3H), 1.88-1.87 (m, 1 H), 1.76 (s, 3H), 1.72 (s, 1 H), 1.52 (s, 1 H). LCMS (Method D): Mass found (M+ 562), Rt (min): 4.64, Area (%): 99.5 (Max), 99.6 (254 nm). HPLC (Method A): Rt (min): 4.61 , Area (%): 98.5 (Max), 99.3 (254 nm).
According to the analysis of related databases, 16793-91-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARES TRADING S.A.; JORAND-LEBRUN, Catherine; SWINNEN, Dominique; GERBER, Patrick; KULKARNI, Santosh; WO2012/130915; (2012); A1;,
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