Electric Literature of 363-51-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 363-51-9, name is 2-Chloro-6-fluoroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of triphosgene (408 mg, 1.37 mmol) in DCM (3 ml) was added 2-chloro-6-fluoro-aniline (200 mg, 1.37 mmol). The RM was cooled to 0 C and treated with triethylamine (402 mu, 2.89 mmol). The RM was stirred at rt for 1 h. The solvent was removed under reduced pressure to give the desired product as a white solid and it was used in the next step without further purification. MS ES+: 204.2 (in methanol).
The synthetic route of 2-Chloro-6-fluoroaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NODTHERA LIMITED; BOCK, Mark G.; WATT, Alan Paul; PORTER, Roderick Alan; HARRISON, David; (229 pag.)WO2019/25467; (2019); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics