Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 18282-59-2, name is 4-Bromo-1,2-dichlorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 18282-59-2
A solution of 1-bromo-3,4-dichlorobenzene (16.92 g, 0.074 mol) in Et2O (100 ml) was added to a suspension of magnesium turnings in Et2O (60 ml) and the mixture was refluxed for 1 hour. The reaction was cooled to 23¡ã C. and a solution of 4-cyanopyridine 54 (7.80 g, 0.075 mol) in 1:1 Et2O:THF (150 ml) was added rapidly with vigorous stirring. The mixture was refluxed for 24 h, then cooled to 23¡ã C. Ice (100 g) was added, followed by 50percent H2SO4 (50 ml), and the mixture was stirred for 1 h. Et2O (100 ml) was added, the aqueous layer was separated, made basic with 10percent NaOH, and extracted with EtOAc (2.x.250 ml). The combined organic layer was dried (Na2SO4), filtered, and concentrated. Purification by silica gel chromatography (eluant: 30percent EtOAc: CH2Cl2) gave 12 g (0.047 mol, 64percent) of the product 55 as a colorless oil. MS (FAB for M+1): m/e 252.
According to the analysis of related databases, 18282-59-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SCHERING CORPORATION; US2005/182095; (2005); A1;,
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