Related Products of 54773-19-2,Some common heterocyclic compound, 54773-19-2, name is 1,2-Dichloro-3-(trifluoromethyl)benzene, molecular formula is C7H3Cl2F3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2,3-dichlorobenzotrifluoride 215 g (1.00 mol) of the compound of the formula (II), anhydrous potassium fluoride 140 g (2.41 mol), sulfolane 2000 mL,10 g of tetraphenylphosphonium bromide was introduced into the autoclave in batches, and the temperature was raised to 250-300 C for 20 hours under stirring. After cooling, the formed potassium chloride and excess potassium fluoride were removed by filtration.The filtrate is rectified, and a fraction of 112 C to 119 C is collected to obtain a compound of formula (III) 2,3-difluorobenzotrifluoride; The residue is further subjected to rectification to collect a fraction of 145 C – 151 C to obtain a by-product 2-fluoro-3-chlorobenzotrifluoride; the by-product can be recycled.The average yield of 2,3-difluorobenzotrifluoride, which is a continuous preparation of the compound of formula (III) after application, is 87.6%.
The synthetic route of 54773-19-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanjing Zheng Rong Pharmaceutical And Chemical Co., Ltd.; Chen Zhengwei; Xiao Tao; Zhu Jiahao; Yu Chuanzong; Dai Jianxin; (13 pag.)CN104693080; (2016); B;,
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