Synthetic Route of 120758-03-4,Some common heterocyclic compound, 120758-03-4, name is 2-Chloro-3,5-dimethoxyaniline, molecular formula is C8H10ClNO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 1-(2,4,6-trifluorophenyl)-1-propanone (7.0 g, 37.2 mmol), 2-chloro-3,5-dimethoxybenzenamine (see European Patent 1333028 for a method of preparation) (6.96 g, 37.1 mmol) and p-toluenesulfonic acid (1.41 g, 8.2 mmol) in toluene (80 mL) was heated at reflux with use of a Dean-Stark trap to remove water. After 20 h, the reaction mixture was cooled to room temperature and diluted with ethyl acetate. The organic layer was washed with water, sulfuric acid (1 N), water and saturated aqueous sodium chloride solution. The organic layer was dried (Na2SO4), filtered and concentrated to provide the title compound (10 g) which was used without further purification in Step C below.
The synthetic route of 120758-03-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; E.I. DU PONT DE NEMOURS AND COMPANY; US2010/160385; (2010); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics