Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 102170-53-6, name is 4-Bromo-5-chloro-2-methoxyaniline, A new synthetic method of this compound is introduced below., SDS of cas: 102170-53-6
Intermediate 7: 2-Amino-5-bromo-4-chlorophenol 4-Bromo-5-chloro-2-methoxyaniline (Intermediate 6, 10g, 42.3 mmol) in DCM (200 mL) was cooled to 0 C. Boron tribromide (21 .2 g, 84.6 mmol) was added drop-wise over 30 min, the reaction mixture was stirred at 0 C for 1 h and then at room temperature for 14 h. The reaction mixture was poured into ice water, sodium hydrogen carbonate was added until pH >7 and aqueous layer was extracted with ethyl acetate (300 mL x 3). The organic phase was dried over magnesium sulphate and the solvent removed under vacuum to give 2-amino-5-bromo-4-chlorophenol as a red solid (8.4 g, 89%, used without further purification for the next step). LCMS (A): Rt 1.46 min, MH+ 222/224.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; BOUILLOT, Anne Marie Jeanne; MIRGUET, Olivier; LIDDLE, John; WALKER, Ann, Louise; WO2015/91647; (2015); A1;,
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