Application of 21402-26-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 21402-26-6, name is 4-Bromo-3-chloroaniline belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 1 Preparation of N,N-Dipentyl-4-bromo-3-chloroaniline (1). 1-Bromopentane (0.42 mL, 3.4 mmol) was added to a mixture of 4-bromo-3-chloroaniline (200 mg, 0.9 mmol) and potassium carbonate (199 mg, 1.4 mmol) in DMF (20 mL) and the reaction was heated to 13 0~~C overnight. The mixture was cooled, diluted with water (20 mL) and extracted with petroleum ether (3*25mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified via flash column chromatography using 9:1 petroleum ether:ethyl acetate as eluent to give N,N-Dipentyl-4-bromo-3-chloroaniline (1) (332 mg, 68%). 1H-NMR (CDCI3) 67.02 (d, IH, ArH); 3.12 (t, 4H, 2*NCH2); 0.95 (t, 6H, 2*CH3). MS; 347 (M+H).
The synthetic route of 4-Bromo-3-chloroaniline has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Oxford Glycosciences (UK) Ltd.; US6262263; (2001); B1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics