Brief introduction of 2,4-Dichloro-1-(trifluoromethyl)benzene

The synthetic route of 320-60-5 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 320-60-5, name is 2,4-Dichloro-1-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., SDS of cas: 320-60-5

Example 3; R-(+)-[2-(2,4-Dichloro-phenyl)-2-(4-fluoro-phenyl)-6-fluoro-benzo[1,3]dioxol-5-yl]-morpholin-4-yl-methanone; Preparation of 2,4-dichloro-4′-fluoro-diphenyldichloromethane; To a cooled (0 C.) suspension of aluminium trichloride (2.02 g, 15 mmol, 3.0 eq.) in 1,2-dichloroethane (7 mL) was slowly added 2,4-dichlorobenzotrifluoride (1.1 g, 5 mmol) followed by fluorobenzene (0.483 g, 5 mmol, 1.0 eq.). The reaction mixture was stirred at 0-5 C. for 5 h, then poured onto ice and extracted with dichloromethane. The combined organic layer was washed with brine, dried over sodium sulfate and filtered. The volatiles were removed in vacuo, affording the title compound (1.63 g, quant.) as yellow oil. MS: m/e=325.0 ([M+H]+).

The synthetic route of 320-60-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Frei, Beat; Plancher, Jean-Marc; Roever, Stephan; Zimmerli, Daniel; US2006/293318; (2006); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics