Application of 102170-53-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 102170-53-6 name is 4-Bromo-5-chloro-2-methoxyaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Preparation of 2-amino-5-bromo-4-chlorophenol (29): To a suspension of 4-bromo-3-chloro-6-methoxyaniline (28) (944 mg, 4 mmol) in 10 ml DCM was added 1 M BBr3 in DCM (8 ml, 8 mmol). The reaction mixture was stirred at r.t. for 2 h, which turned to a brown solution and back to a brown suspension. After quenched with aq. sodium bicarbonate solution, the mixture was extracted with EA. The org. phase was washed with brine, dried over sodium sulfate, concentrated to dryness to give 865 mg of 29 as a brown solid. Yield: 97.2%, purity>95%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-5-chloro-2-methoxyaniline, and friends who are interested can also refer to it.
Reference:
Patent; CalciMedica, Inc.; US2011/263612; (2011); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics