Related Products of 202865-57-4, A common heterocyclic compound, 202865-57-4, name is 1-Bromo-2,5-dichloro-3-fluorobenzene, molecular formula is C6H2BrCl2F, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Preparation 19 1-Bromo-2,5-dichloro-3-methoxybenzene 1-Bromo-2,5-dichloro-3-fluorobenzene (40 g, 0.16 mol) and sodium methoxide (44.3 g, 0.82 mol) were stirred in methanol (500 ml) at the reflux temperature for 16 hours. The reaction was cooled to ambient temperature then quenched with water (500 ml). The mixture was extracted with diethyl ether (3*300 ml), dried (Na2SO4) and evaporated to afford the product as a white solid (40 g) 1H-NMR (CDCl3): 3.90 (s, 3H), 6.86 (d, 1H), 7.26 (d, 1H). MS m/z 256 [MH]+ GC-MS m/z 256 [MH]+, Rt=4.58 min
The synthetic route of 202865-57-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Pfizer Limited; US2007/105872; (2007); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics