Electric Literature of 2162-98-3, These common heterocyclic compound, 2162-98-3, name is 1,10-Dichlorodecane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5.68 g (0.05 M) of 4-chloropyridine was dissolved in 50 mL of dimethylformamide, and 15.63 g (0.025 M) of 1,10-dichlorodecane was separately dissolved in 170 mL of dimethylformamide. The 4-chloropyridine solution And the reflux reaction was carried out at 150 DEG C for 20 hours while slowly dropping at 100 DEG CWhen the thin layer chromatography phase reaction is completed, the reaction is stopped by adding about 20 mL of boiling water while cooling the reaction solution. The resulting solution is cooled to 0 C, made alkaline with 35% sodium hydroxide solution and extracted with dichloromethane doThe organic layer was washed with water and then magnesium sulfate was added to remove the water. The solution was distilled under reduced pressure to remove the solvent. 10.53 g of bis (4-chloropyridin-1 (4H) (Yield: 57.0%)
Statistics shows that 1,10-Dichlorodecane is playing an increasingly important role. we look forward to future research findings about 2162-98-3.
Reference:
Patent; Firson Co.,Ltd; Kim, Dong Jin; Koo, Chang Hwei; Park, Sung Yong; Cho, Ir Hwe; Lee, Sung Bae; Han, Dong Hoon; (12 pag.)KR2017/13425; (2017); A;,
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