Electric Literature of 467435-07-0,Some common heterocyclic compound, 467435-07-0, name is 4-Bromo-2-chlorobenzotrifluoride, molecular formula is C7H3BrClF3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Into a glass reaction vessel equipped with a stirrer and having a capacity of 250 mL,7.2 g (68.0 mmol) of sodium carbonate,2.6 g (20.4 mmol) of 2-thiopheneboronic acid,4-Bromo-2-chlorobenzotrifluoride 2.5 mL(17.0 mmol), dehydrated toluene 102 mL, dehydrated ethanol 51 mL,And 2.0 g (1.7 mmol) of tetrakistriphenylphosphine palladium,And the mixture was reacted at 80 C. for 16 hours.Water was added to the reaction product, and the mixture was extracted with methylene chloride.After drying with magnesium sulfate and distilling off the solvent under reduced pressure, purification by silica gel column chromatography (hexane) gave 4.4 g of compound (C11-c) as a white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-2-chlorobenzotrifluoride, its application will become more common.
Reference:
Patent; Ube Industries Ltd; Tanaka, Yasuhiro; Homma, Takashi; (66 pag.)JP2018/168138; (2018); A;,
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