Synthetic Route of 1161847-36-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1161847-36-4, name is 6-Chloroimidazo[1,2-b]pyridazin-8-amine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 13.; Reference for Suzuki conditions: Billingsley and Buchwald, J. Am. Chem. Soc. 2007, 129, 3358-3366. A mixture of 6-chloro-imidazo[l,2-b]pyridazin-8-ylamine (0.048 g, 0.29 mmol), 4-tert- butyl-N-[2-methyl-3-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl)-phenyl]-benzamide (0.169 g, 0.444 mmol), potassium phosphate (0.120 g, 0.567 mmol), 2- dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (0.024 g, 0.058 mmol), palladium acetate (0.007 g, 0.03 mmol), 0.5 mL of n-butanol and 0.2 mL of water in a sealed tube was stirred at 100 0C for 2 d. The resulting cloudy orange mixture was partitioned between 5 mL of ethyl acetate and 5 mL of water, and the aqueous layer was extracted with 5 mL of ethyl acetate. The combined organic layers were dried over MgSO4, filtered and concentrated to an orange oil. Column chromatography (60 -> 100% EtOAc/hexanes) afforded 0.026 g (23%) of N-[3-(8-amino-imidazo[l,2-b]pyridazin-6-yl)-2-methyl- phenyl] -4-tert-butyl-benzamide as a yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Chloroimidazo[1,2-b]pyridazin-8-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2009/77334; (2009); A1;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics