Synthetic Route of 54730-35-7,Some common heterocyclic compound, 54730-35-7, name is 3,5-Dichloro-4-methylaniline, molecular formula is C7H7Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 3,5-dichloro-4-methylaniline (0.9 mmol, 157.5 mg) in dimethyl sulfoxide (3.0 mL) is added carbodiimidazole (1.1 mmol, 178.4 mg) and stirred at room temperature for 2 hours. did.Then, 2,4-dibromo-6- (1H-tetrazol-5-yl) aniline (1.0 mmol, 319.0 mg) and triethylamino(1.0 mL) was added and stirred at room temperature for 24 hours. After heating under reduced pressure and distilling off the solvent, the resulting solid was dissolved in ethyl acetate (300 mL) and extracted three times with a saturated aqueous ammonium chloride solution (100 mL).The organic layers are combined and dried over magnesium sulfate, and the solvent is distilled off under reduced pressure.It was. The resulting solid was washed with toluene and ethyl acetate, dissolved in methanol, and subjected to silica gel column chromatography (ethyl acetate: methanol = 1: 1) to give UA-44 (12.0 mg, yield 3%). Was obtained as a white solid.
The synthetic route of 54730-35-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tohoku University; Uozumi, Nobuyuki; Arisawa, Mieko; Suzuki, Futoshi; Endo, Akira; Hamamoto, Susumu; Ikenokami, Yoshiaki; (20 pag.)JP2019/137678; (2019); A;,
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