Synthetic Route of 1298031-94-3, These common heterocyclic compound, 1298031-94-3, name is 8-Bromo-6-chloro-2-methylimidazo[1,2-b]pyridazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
8-Bromo-6-chloro-2-methylimidazo[l,2-b]pyridazine (500 mg, 2.0 mmol, prepared according to Example 43) was combined with K2C03 (550 mg, 4.0 mmol) and lH-imidazole (250 mg, 0.36 mmol) in NMP (5 mL). The mixture was stirred at 120 C for 16 h. The mixture was partitioned between EtOAc and H20. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated. The residue was chromatographed on silica gel, eluting with 0-30% EtOAc in petroleum ether to yield 6-chloro-8-(lH-imidazol-l-yl)-2-methylimidazo[l,2-b]pyridazine (228 mg, 48%). MS m/z 234.0, 236.0 [M+H]+.
The synthetic route of 1298031-94-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PTC THERAPEUTICS, INC.; WOLL, Matthew, G.; AMEDZO, Lukiana; BABU, Suresh; BARRAZA, Scott, J.; BHATTACHARYYA, Anuradha; KARP, Gary, Mitchell; MAZZOTTI, Anthony, R.; NARASIMHAN, Jana; PATEL, Jigar; TURPOFF, Anthony; XU, Zhenrong; (251 pag.)WO2018/226622; (2018); A1;,
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