Related Products of 179897-90-6, A common heterocyclic compound, 179897-90-6, name is 1,3-Dibromo-2-chloro-5-fluorobenzene, molecular formula is C6H2Br2ClF, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 150 mL of DMF (dimethylformaldehyde), 1,3-dibromo-2-chloro-5-fluorobenzene (23.0 g, 79.8 mmol), dimethylamine (24.3 g, 144 mmol) and cesium carbonate (84.4 g, 239 mmol) were added thereto, and the mixture was heated to 140 C and reacted for 40 hours. After cooling to room temperature, the mixture was extracted with EA, dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. This was subjected to column chromatography with EA: Hx to obtain 12.0 g (Yield = 34%) of [Intermediate 7-1].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; LG Chem, Ltd.; Gu Gi-dong; Lee Gi-gon; Keum Su-jeong; Yoon Jeong-min; Lee Hyeong-jin; Kim Gong-gyeom; (57 pag.)KR2018/112722; (2018); A;,
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