Synthetic Route of 2162-98-3,Some common heterocyclic compound, 2162-98-3, name is 1,10-Dichlorodecane, molecular formula is C10H20Cl2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1,10-Dichlorodecane (8.73 g, 41.3 mmol) and triethylamine (6 mE) were added to a solution of m-aminophenol (3.85 g, 35.3 mmol) in DMF (40 mE). The mixture was stirred at 1000 C. for 3 days. The reaction was quenched with sam- 40 rated aqueous NaHCO3 and extracted with EtOAc. The combined organic layer was washed with brine, dried over anhydrous MgSO4, filtered, and concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, hexane_EtOAc=9:i to 1:1) to give the title compound (1.92 g, 6.76 mmol, 19% yield). Brown oil; R1=0.57 (33% EtOAc-hexane); ?H NMR (600 MHz, DM50- d5) oe 8.84 (s, 1H), 6.80 (dd, J=7.6, 8.3 Hz, 1H), 5.97 (d, J=7.6 Hz, 1H), 5.94 (s, 1H), 5.92 (d, J=8.2 Hz, 1H), 5.36 (s, 1H), 50 3.61 (m, 2H), 2.89 (m, 2H), 1.69 (m, 2H), 1.49 (m, 2H),1.35-1.25 (m, 12H); ?3C NMR (150 MHz, DMSO-d5) oe158.3, 150.6, 129.5, 103.7, 103.0,98.9,45.6,43.1,32.2,29.2,29.1 x2, 28.9,28.4,26.9,26.4; FABMS m/z 283 [M]; HRMS calcd. for C,6H26N0C1 [M] 283.1703. found 283.1708. 55theoil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,10-Dichlorodecane, its application will become more common.
Reference:
Patent; KYOTO UNIVERSITY; Uesugi, Motonari; Hirata, Nao; Murata, Asako; Chang, Young-Tae; Nakatsuji, Norio; Suemori, Hirofumi; Kawase, Eihachiro; Yamauchi, Kaori; Ueda, Kazumitsu; Fujibayashi, Yuto; Yamanaka, Shinya; Nakagawa, Masato; (34 pag.)US9335323; (2016); B2;,
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