Electric Literature of 1303588-27-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1303588-27-3, name is 7-Chloro-1,2,3,4-tetrahydro-1,8-naphthyridine, This compound has unique chemical properties. The synthetic route is as follows.
The mixture of 7-chloro-l,2,3,4-tetrahydro-l,8-naphthyridine (110; 6.0 g, 35.7 mmol), Boc20 (15.6 g, 71.4 mmol) and 4-Dimethylaminopyridine (DM AP) (13.1 g, 107.1 mmol) in THF(200 mL) was stirred under reflux for overnight. TLC showed the reaction was complete and the mixture was poured into water. The organic layer was dried over anhydrous Na2S04, filtered and concentrated to give /er/-butyl 7-chloro-3,4-dihydro-l,8-naphthyridine-l(2H)-carboxylate (112; 8.74 g, 91%) as a white solid. MS (ESI) calcd for C13H17CIN2O2 (m/z) 268.74.
The chemical industry reduces the impact on the environment during synthesis 7-Chloro-1,2,3,4-tetrahydro-1,8-naphthyridine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; NG, Pui, Yee; BLUM, Charles; MCPHERSON, Lauren; PERNI, Robert, B.; VU, Chi, B.; AHMED, Mohammed, Mahmood; DISCH, Jeremy, S.; WO2011/59839; (2011); A1;,
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