Related Products of 2162-98-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2162-98-3, name is 1,10-Dichlorodecane belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
A mixture of 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine (0.45 g, 2.44 mmol), 1,10-dichlorodecane (0.25 g, 1.2mmol), and sulfolane (2 mL) was heated at 190-200 C for 90 h. The resulting mass was stirred with methanol and filtered. The filtrate was concentrated and chromatographedon an Al2O3 column using a gradient from 1 to 25% ofmethanol in methylene chloride. Fractions containing required product were pooled together and evaporated, andthe resulting off-white solid (31 mg, 4.5%) was further purified by crystallization from a methanol/acetone mixture [Mp 250-258 C (dec). 1H NMR (500 MHz, CDCl3) delta1.27-1.43 (m, 12 H), 1.67-1.76 (m, 4 H), 2.20-2.26 (m, 4H), 2.95 (t, 4 H, J = 7.5 Hz), 3.38 (t, 4 H, J = 7.5 Hz), 3.63(t, 4 H, J = 7.0 Hz), 4.46 (t, 4 H, J = 6.5 Hz),7.72 (t, 2 H, J = 7.0 Hz), 7.98 (t, 2 H, J = 7.5 Hz),8.15 (d, 2 H, J = 9.0 Hz), 8.54 (d with fine splitting, 2 H,J = 8.5 Hz), 8.92 (br s, 4 H, NH2).
The synthetic route of 1,10-Dichlorodecane has been constantly updated, and we look forward to future research findings.
Reference:
Article; Sharma, Arun K.; Krzeminski, Jacek; Weissig, Volkmar; Hegarty, John P.; Stewart, David B.; Journal of Antibiotics; vol. 71; 8; (2018); p. 713 – 721;,
Chloride – Wikipedia,
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