Some common heterocyclic compound, 1009102-44-6, name is 1-(4-Chlorophenyl)cyclopropanamine hydrochloride, molecular formula is C9H11Cl2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C9H11Cl2N
Step 2: To a suspension of 4-(4-chloiO-6-(2,2?2-trifluoroethoxy)-l,3,5-triazin-2- ylamino)faenzenesulfonamide from step 1 (1 g, 2.61 mmol) in THF (20 mL) was added l-(4-chlorophenyl)cyclopropanamine, HC1 (0.53 g, 2.61 mmol) and iPr2NEt (1.35 mL, 10.4 mmol). The mixture was heated at reflux condition for 16 hours. The solvent was removed under vacuum. The crude product 4-(4-(l -(4- chlorophenyl)cyclopropylamino)-6-(2}2,2-trifiuoroethoxy)-l,3J5-triazm-2- ylamino)benzenesulfonamide was used directly in the next step without further purification. LC-MS (Condition A), MS m/z 514.9 (M+ +H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1009102-44-6, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; SUN, Li-Qiang; MULL, Eric; ZHAO, Qian; WANG, Tao; ZHANG, Zhongxing; SCOLA, Paul Michael; WO2012/24373; (2012); A1;,
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