Application of 179897-90-6, A common heterocyclic compound, 179897-90-6, name is 1,3-Dibromo-2-chloro-5-fluorobenzene, molecular formula is C6H2Br2ClF, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
DMF (dimethylformaldehyde)To a solution of 1,3-dibromo-2-chloro-5-fluorobenzene (23.0 g, 79.8 mmol)And di-tert-butylphenylamine (24.3 g, 144 mmol)And cesium carbonate (84.4 g, 239 mmol) were charged, and the mixture was heated to 140 C and reacted for 40 hours.After cooling to room temperature, the mixture was extracted with EA, dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure.This was subjected to column chromatography with EA: Hx to obtain 12.0 g (Yield = 34%) of [Intermediate 12-1].
The synthetic route of 179897-90-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG Chem, Ltd.; Gu Gi-dong; Yoon Jeong-min; Kim Gong-gyeom; Huh Nan-seul-a; Lee Gi-gon; Keum Su-jeong; (52 pag.)KR2018/112721; (2018); A;,
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