Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 467435-07-0, name is 4-Bromo-2-chlorobenzotrifluoride, A new synthetic method of this compound is introduced below., Computed Properties of C7H3BrClF3
j00628j To a mixture of 4-bromo-2-chloro-1-(trifluoromethyl)benzene (0.11 g, 0.44 mmol) and compound (R)-A-2 (0.10 g, 0.55 mmol) in dioxane (10 mL) under nitrogen at room temperature was added cesium carbonate (0.36 g, 1.1 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (32 mg, 0.050 mmol) and tris(dibenzylideneacetone)dipalladium(0) (25 mg, 0.028 mmol). The reaction mixture was stirred at 106 C for 2 hours, then filtered and concentrated in vacuo. The residue was purified by prep-HPLC [Instrument: Shimadzu pump LC-20A; Column: GEMiNI 200 x 50 mm, particle size: 10 jim; Mobile phase: 55-66.7% acetonitrile in H20 (add 0.5% NH3 H20, v/v)j. The combined fractions were lyophilized, treated with 0.2 M hydrochloric acid and again lyophilized to give:Compound (R)-35 (65 mg, 37% yield) as a white solid: cSFC analytical tR=2.60 mm., purity: 100%; LCMS (M): tR=2.42 mm., 360.1 m/z (M+1); ?H-NMR (CD3OD, 400 MHz): 7.79 (s, 1H), 7.65 (d, J=8.8 Hz,1H), 7.43 (d, J=8.4 Hz,1H), 3.71-3.61 (m, 2H), 3.48-3.42 (m, 2H), 3.39-3.36 (m, 4H), 2.46-2.39 (m, 2H), 2.16-2.08 (m, 1H), 2.03-1.90 (m, 2H).
The synthetic route of 467435-07-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FORUM PHARMACEUTICALS, INC.; ACHARYA, Raksha; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; COOK, Andrew, Simon; HARRISON, Bryce, Alden; McRINER, Andrew, J.; (267 pag.)WO2017/69980; (2017); A1;,
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