Application of 1206825-03-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1206825-03-7, name is 4-Chloroimidazo[2,1-f][1,2,4]triazine belongs to chlorides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Example 4: 3-((3R,4R)-3-(Imidazo[l,2^] [l,2,4]triazin-4-yl(methyl)amino)-4-methylpiperidin- l-yI)-3-oxopropanenitrile (34)34 To a solution of 4-chloroimidazo[l,2-/J[l,2,4]triazine (33) (0.23 mg, 1 mmol) and 3-((3i?,4i?)-4-methyl-3-(methylamino)piperidin-l-yl)-3-oxopropanenitrile (21) (0.15 g, 1 mmol) in dioxane water (3:8 mL) was added NaHCO3 (0.084 g, 1 mmol). The mixture was heated in a microwave at 100 0C for 30 min and concentrated in vacuum. The residue obtained was purified by flash column chromatography (silica gel 12 g, eluting with 0-20% CMA-80 in chloroform) to furnish 3-((3/?,4i?)-3-(Imidazo[ 1 ,2-/J [ 1 ,2,4]triazin-4-yl(methyl)amino)-4-methylpiperidin- 1 -yl)-3- oxopropanenitrile (34) (0.05 g, 16%) as an off-white solid; mp 72.0 0C. 1H NMR (300 MHz, DMSO) delta 8.11 (s, IH), 8.05 (s, IH), 7.62 (s, IH), 6.45-5.73 (m, IH), 4.08 (s, 2H), 3.87 (s, 3H), 3.40 (s, 3H), 2.47-2.34 (m, IH), 1.89-1.50 (m, 2H), 1.01 (s, 3H); MS 314.1 (100%, M+l, ES^).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloroimidazo[2,1-f][1,2,4]triazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; CHAND, Pooran; KOTIAN, Pravin, L.; KUMAR, V., Satish; WO2010/14930; (2010); A2;,
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics